abstract：BACKGROUND:The pathological mechanisms underlying peroxisomal biogenesis disorders (PBD) are not fully understood and the available therapies are not sufficient. This stresses the importance of identifying biochemical markers that reflect the extent of peroxisomal dysfunction in plasma of PBD patients. METHODS:Very lo...

journal_title：Clinical laboratory

authors： Ghoneim W,El-Bassyouni HT,Abdel Maksoud SA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the alterations in calcium and lipid peroxidation in red blood cells (RBCs) and serum samples of continuous ambulatory peritoneal dialysis (CAPD) patients. We also investigated the relationship between parathyroid hormone (PTH) and calcium homeostasis in this study. METH...

journal_title：Clinical laboratory

authors： Sahin E,Goçmen AY,Gümüşlü S,Sahin M,Koçak H,Tuncer M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate reference intervals for complete blood cell count parameters among apparently healthy 1,807 adults from Addis Ababa, Ethiopia. METHODS:Blood specimens were collected from each participant using standard procedures. The collected aliquots were processed according t...

journal_title：Clinical laboratory

authors： Gelaye B,Bekele T,Khali A,Haddis Y,Lemma S,Berhane Y,Williams MA

更新日期：2011-01-01 00:00:00

abstract：:1960 Theodore Maiman built the first Ruby-LASER, starting-point for half a century of R&D on Biomedical LASER continuous improvement. The purpose of this paper is to contribute a review of the often disregarded, however, extremely important Industrial Property documents of LASER-based in vitro Diagnostics devices. It ...

journal_title：Clinical laboratory

authors： Spyropoulos B

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Hemoglobin Q-Iran is a rare variant which has not been described in association with alpha-thalassemia to date. We present the case of a Turkish patient who developed spinal ischemia. METHODS:Spinal ischemia was diagnosed clinically, via magnetic resonance imaging and angiographically. Blood samples were an...

journal_title：Clinical laboratory

authors： Zur B,Hildesheim A,Ludwig M,Stoffel-Wagner B

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Diabetic patients undergoing percutaneous coronary intervention (PCI) have a worse prognosis than non-diabetic patients. The anti-oxidized LDL antibodies (anti-LDLox ab) have recently been suggested to be protective against the development of diabetes. The aim of this study was to compare the levels of IgG a...

journal_title：Clinical laboratory

authors： Garrido-Sánchez L,García-Pinilla JM,Jiménez-Navarro M,Fernández-Pastora J,Alonso-Briales JH,Hernández-Garcia JM,De-Teresa-Galván E,Tinahones FJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The increased incidence of coronary artery disease (CAD) in patients with conventional cardiovascular risk factors cannot be fully explained by the known risk factors. The aim of the study was to test whether there is an association between the levels of serum total PSA with the presence of CAD and its sever...

journal_title：Clinical laboratory

authors： Boroumand MA,Anvari MS,Amelimojarad E,Shoar S,Naderan M,Yazdanifard P,Karimi A,Goodarzynejad H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Pneumatic tube sample transport is widely used in hospitals because it is convenient and reduces turnaround times. However, the preanalytical effects of pneumatic tube transport of blood samples on platelet function analysis are not fully understood. METHODS:Blood samples from 15 healthy subjects were colle...

journal_title：Clinical laboratory

authors： Hübner U,Böckel-Frohnhöfer N,Hummel B,Geisel J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To determine the diagnostic performances of anti-cyclic citrullinated peptide antibodies (anti-CCP) type IgM, IgA and IgG and rheumatoid factor (RF) in Syrian patients with rheumatoid arthritis. METHODS:64 patients with rheumatoid arthritis were included in our study. Anti-CCP IgM, IgA and IgG and rheumatoi...

journal_title：Clinical laboratory

authors： Awwad HM,Aboukhamis I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To investigate the markers of systemic function by using laboratory parameters as life parameters. METHODS:Lymphocyte count, albumin, and creatinine levels were measured using automatic analyzers in young, healthy individuals (20-39 years) and senior individuals (80-95 years) as well as in terminally ill pa...

journal_title：Clinical laboratory

authors： Hongwei W,Xinyu Z,Guihong L,Xiliang L,Hui L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Recent studies indicated that soluble OX40 ligand (OX40L) levels were increased in acute coronary syndrome. But the association between sOX40L and carotid intima-media thickness (IMT) has not been evaluated. METHODS:We measured plasma soluble OX40L (sOX40L) and Interleukin-10 (IL-10) levels in 35 patients w...

journal_title：Clinical laboratory

authors： Peng DQ,Huang S,Yuan SG,Zhao SP

更新日期：2010-01-01 00:00:00

abstract：:With the redefinition of myocardial infarction in 2000, cardiology associations ESC and ACC require the use of the 99th percentile of a healthy population at a coefficient of variation (CV) of less than 10 % for Troponin values in diagnosing myocardial infarction. With a new Troponin T high sensitive (TnThs) assay as ...

journal_title：Clinical laboratory

authors： Bertsch T,Braun SL,Giannitis E,Knebel F,Weber M,Christ M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:In light of increasing attention focused on patient safety and the need to reduce laboratory mistakes, it is crucial for clinical laboratories to collect statics on error rates over the whole testing cycle, particularly on the pre-analytical phase. METHODS:Memorial Hospital has a laboratory service providin...

journal_title：Clinical laboratory

authors： Tekkesin N,Kilinc C,Keskin K

更新日期：2010-01-01 00:00:00

abstract：:This article mainly describes the effects of boric acid and borates often used as bacteriostatic agents in urine collection for microbiological examination, on the results obtained in the measurement of uric acid in urine using the uricase [EC.1.7.3.3] method. The bias in results is not unidirectional, the spread of r...

journal_title：Clinical laboratory

authors： Wood WG

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to compare whether oxidized LDL (oxLDL), anti-oxLDL and anti-annexin (anx) A5 antibodies are associated with clinical features of primary antiphospholipid syndrome (PAPS), and to compare these to well-defined groups of non-PAPS myocardial infarction survivors (non-PAPS MI) and to non-PAPS pat...

journal_title：Clinical laboratory

authors： Becarevic M,Singh S,Majkic-Singh N

更新日期：2008-01-01 00:00:00

abstract：:Competitive ELISAs for advanced glycation end product (AGE) measurements are based on anti-AGE-antibody and in vitro prepared AGE-carrier competitive antigen. AGE-human serum albumin (HSA) prepared by non-enzymatic reaction between protein and glucose is often used as a competitive antigen. The aim of the study was to...

journal_title：Clinical laboratory

authors： Benko B,Turk Z

更新日期：2008-01-01 00:00:00

abstract：:We developed a public Internet program called SimChip (www.simchip.de). It performs virtual "in silico experiments", which reflect the in vivo situation of gene expression. Our computer model simulates up- and downregulation of genes on the basis of differential equations for linear synthesis and non-linear decay of m...

journal_title：Clinical laboratory

authors： Hoffmann G,Ostermeir R,Müller H,Bitterlich N,Martus P,Neumaier M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Glutamic acid decarboxylase antibodies (GADA) and tyrosine phosphatase antibodies (islet antigen-2 antibodies; IA-2A) are used in clinical practise to identify type 1 diabetes. METHODS:GADA and IA-2A were measured with RSR-ELISA kits in samples from 76 newly diagnosed type 1 diabetic children and 120 health...

journal_title：Clinical laboratory

authors： Rahmati K,Lernmark A,Becker C,Foltyn-Zadura A,Larsson K,Ivarsson SA,Törn C

更新日期：2008-01-01 00:00:00

abstract：:The glomerular filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations of creatinine or cystatin C. Recently, it has been recommended that an estimated GFR...

journal_title：Clinical laboratory

authors： Dajak M,Ignjatović S,Jovicić S,Majkić-Singh N

更新日期：2008-01-01 00:00:00

abstract：:A number of clinically important conditions is associated with insulin resistance and compensatory hyperinsulinemia. Since there is growing evidence that serum insulin measurement can be useful for the individual characterization of the metabolic situation, we aimed to study the agreement of serum insulin results obta...

journal_title：Clinical laboratory

authors： Vogeser M,Parhofer KG

更新日期：2007-01-01 00:00:00

abstract：:The diagnosis and monitoring of free light chain abnormalities and disease has always been a challenging area for laboratory and clinical staff because urine electrophoresis is often overlooked in the investigations requested. We present here three case reports which illustrate first, the role of the laboratory staff ...

journal_title：Clinical laboratory

authors： Sinclair D,Wainwright L

更新日期：2007-01-01 00:00:00

abstract：:External quality assessment surveys for thyroid-related antibodies have been offered by INSTAND for 20 years. During this time, some problems have remained, especially those between the similarity of samples sent and routine patient samples. Here the questions of "matrix effects" and "commutability of results" are top...

journal_title：Clinical laboratory

authors： Wood WG

更新日期：2007-01-01 00:00:00

abstract：:Our manuscript describes the investigation of options for the detection and semiquantitative assay of drug (metabolites) and the assay of relevant pharmaceutical active substances using the LX20 PRO (Beckman Coulter) in comparison with the Dimension RxL (Dade Behring) and the TDx or AxSYM (Abbott) system. Drug tests c...

journal_title：Clinical laboratory

authors： König H,Lestin HG,Brinkmann T,Augsten M,Kotira B

更新日期：2007-01-01 00:00:00

abstract：:Human mesenchymal stem cells (HMSCs) which are isolated from bone marrow stroma, peripheral blood, dermis, muscle and adipose tissue have the advantage of potential autologous transplantation ability. They can be differentiated into chondrogenic, osteogenic, adipogenic and myogenic lineages. Problems of stem cells fro...

journal_title：Clinical laboratory

authors： Pansky A,Roitzheim B,Tobiasch E

更新日期：2007-01-01 00:00:00

abstract：:An immunoassay of sirolimus based on the microparticle enzyme immunoassay (MEIA) principle was evaluated on 105 whole blood samples (EDTA) drawn from a population of renal (n = 38) and hepatic or heart (n = 3) transplant patients. Each blood sample was analyzed simultaneously by MEIA and by a liquid chromatography mas...

journal_title：Clinical laboratory

authors： Scholer A,Von Rickenbach R,Faffa G,Vetter B

更新日期：2006-01-01 00:00:00

abstract：:A total of 752 fecal specimens collected during the period of July 2004 to June 2005 from infants and children with acute gastroenteritis from four different regions (Maizuru, Tokyo, Sapporo, and Osaka) of Japan were tested for the presence of norovirus by RT-PCR. It was found that 139 (18.5%) fecal specimens were pos...

journal_title：Clinical laboratory

authors： Phan TG,Takanashi S,Kaneshi K,Ueda Y,Nakaya S,Nishimura S,Sugita K,Nishimura T,Yamamoto A,Yagyu F,Okitsu S,Maneekarn N,Ushijima H

更新日期：2006-01-01 00:00:00

abstract：:Maturity-onset diabetes of the young (MODY) is a dominantly inherited form of non-ketotic diabetes. It usually develops in childhood, adolescence or young adulthood. The disease is heterogenous regarding the genetic and clinical features. Until now, 6 causal genes have been identified. According to clinical evidence t...

journal_title：Clinical laboratory

authors： Olek K

更新日期：2006-01-01 00:00:00

abstract：:Capillary zone electrophoresis of serum proteins is increasingly gaining impact in clinical laboratories. During 2003, we compared the fully automated capillary electrophoresis (CE) system from Beckman (Paragon CZE 2000) with the method agarose gel electrophoresis Sebia (Hydrasis-Hyris, AGE). This new study focused on...

journal_title：Clinical laboratory

authors： Roudiere L,Boularan AM,Bonardet A,Vallat C,Cristol JP,Dupuy AM

更新日期：2006-01-01 00:00:00

abstract：:Osteoporosis, chronic heart failure (CHF) and mild to moderate hyperhomocysteinemia (HHCY) can frequently be found in elderly individuals and often occur in the same individual. Due to demographic changes in the number of elderly people the total number of individuals suffering from osteoporosis and/or CHF, and hence ...

journal_title：Clinical laboratory

authors： Herrmann M,Taban-Shomal O,Müller S,Gunter L,Hübner U,Böhm M,Herrmann W

更新日期：2006-01-01 00:00:00

abstract：:It is known that the erythrocyte sedimentation rate is related to the erythrocyte concentration in blood. Recently, some authors have proposed a method for estimating the relation between the Westergren erythrocyte sedimentation rate and the erythrocyte sedimentation rate adjusted on an hematocrit of 0.35 L/L. In this...

journal_title：Clinical laboratory

authors： Giavarina D,Capuzzo S,Pizzolato U,Soffiati G

更新日期：2006-01-01 00:00:00

abstract：:The total homocysteine (tHcy) plasma concentration increases 10% per hour when whole blood is collected on ethylene diamine tetraacetate (EDTA) and stored at room temperature. The aim of this study was to investigate the stability of tHcy plasma concentration during 24 hours of storage at room temperature in two diffe...

journal_title：Clinical laboratory

authors： Wolff F,Gausset P,Vanderpas J

更新日期：2005-01-01 00:00:00

abstract：:Adiponectin is a serum protein secreted by adipocytes and accounts for approximately 0.01% of total plasma protein. In healthy patient populations adiponectin can be found in concentrations of 7-12 mg/l. Unlike other adipocyte products, adiponectin correlates with decreased free fatty acid blood concentrations and red...

journal_title：Clinical laboratory

authors： Schöndorf T,Maiworm A,Emmison N,Forst T,Pfützner A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Fibromyalgia syndrome (FM) is a disease with widespread chronic pain and many nonspecific symptoms. Hyaluronic acid (HA) is a disputed marker for the diagnosis of FM. The aim of the study is to clarify the discrepant results reported so far. METHODS:Serum concentrations of HA were measured with a radiometri...

journal_title：Clinical laboratory

authors： Werle E,Jäkel HP,Müller A,Fischer H,Fiehn W,Eich W

更新日期：2005-01-01 00:00:00

abstract：:The measurement of androgen levels is important in the follow-up of sexual development and in the diagnosis of disturbances of the gonadal function in children and adults. The aim of this study was to evaluate the age dependence of the serum concentrations of testosterone, androstenedione, and SHBG from birth until ol...

journal_title：Clinical laboratory

authors： Elmlinger MW,Kühnel W,Wormstall H,Döller PC

更新日期：2005-01-01 00:00:00

abstract：:A Central laboratory that participates in multicenter clinical studies must consider and study the parameters that condition the in vitro stability of the analytes. We evaluated the effect of temperature on serum C-peptide storage during transport from clinical research centers to the Central laboratory. In particular...

journal_title：Clinical laboratory

authors： Bolner A,Lomeo L,Lomeo AM

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The Hitachi CLA allergy test gives individual results on a wide range of common allergens. This study looked at the effect on patient management of the extra information gleaned from the use of this test compared to the same patient being investigated under a protocol of a total IgE and 4 allergen specific...

journal_title：Clinical laboratory

authors： Sinclair D,Saas M,Cook LJ

更新日期：2005-01-01 00:00:00

abstract：:Mutant forms of hepatitis B surface antigen have developed from a matter of academic interest into a real threat due to the fact that they may remain undetected by certain commercial immunoassays. The risk is especially high when hepatitis B surface antigen is the only strategy to detect an asymptomatic HBV carrier in...

journal_title：Clinical laboratory

authors： Levicnik-Stezinar S

更新日期：2004-01-01 00:00:00

abstract：:To investigate the detectability and expressiveness of salivary and fecal anti-gliadin (AGA), anti-endomysium (EMA) and anti-tissue-transglutaminase (ATA) antibodies, 127 salivary and 160 fecal samples of healthy volunteers and salivary and fecal samples of 17 patients with histologically proven and 9 patients with su...

journal_title：Clinical laboratory

authors： Halblaub JM,Renno J,Kempf A,Bartel J,Schmidt-Gayk H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:This report describes a differential staining method which distinguishes gram-positive from gram-negative bacteria in fluorescence. Gram-positive bacteria appear yellow and gram-negative bacteria appear green. MATERIAL AND METHODS:The method is based on two fluorochromes, one acting in the wavelength of red...

journal_title：Clinical laboratory

authors： Ciancaglini E,Fazii P,Sforza GR

更新日期：2004-01-01 00:00:00

abstract：:We studied the serum HER-2 extracellular domain (sHER-2) before the first metastases in 128/701 breast cancer patients diagnosed and followed-up in our institution who developed metastases as the first relapse. sHER-2 was measured by an enzyme-linked immnunosorbent assay and CA 15.3 by an immunoradiometric assay. Non-...

journal_title：Clinical laboratory

authors： Pichon MF,Hacene K,Guepratte S,Neumann R

更新日期：2004-01-01 00:00:00